产品货号：
Z30721
中文名称：
SCUBE3抗体
英文名称：
Anti-SCUBE3 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SCUBE3 Antibody |
| 指标别名 | CEGF3;SCUBE3 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,IHC |
| 基因名称 | SCUBE3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | SCUBE3 antibody was raised against a 15 amino acid peptide near the center of human SCUBE3.The immunogen is located within amino acids 440 - 490 of SCUBE3. |
| 计算分子量 | 109kDa |
| 成分 | SCUBE3 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | SCUBE3 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones,and to a lesser extent in heart (1,2).Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy,suggesting that it may also play a role in the regulation of cardiac growth.SCUBE3 has been shown to be an endogenous TGF-beta receptor ligand (3,4) and is thought to promote lung cancer cell mobility and invasiveness.In lung cancer cells,the secreted SCUBE3 protein was cleaved by MMP2 and MMP9,allowing the activation of the TGF-beta receptor,the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-beta1,VEGF,Snail,and Slug. |
| Uniprot ID | Q8IX30 |
| 基因名全称 | Signal peptide,CUB and EGF-like domain-containing protein 3 precursor |
| 蛋白名全称 | Signal peptide,CUB and EGF-like domain-containing protein 3 precursor |
| 推荐稀释比 | SCUBE3 antibody can be used for detection of SCUBE3 by immunohistochemistry at 5μg/mL.Antibody validated:Immunohistochemistry in human samples.All other applications and species not yet tested. |
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